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WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinsons disease

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Research uses MT-1 to establish the reference pharmacodynamic profile for MC1R activation , characterising concentration-response relationships, receptor internalisation kinetics, and downstream melanin synthesis biology that serve as the benchmark for evaluating other melanocortin agonists and antagonists at MC1R

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ChaC2 is on chromosome 2p16.2 and encodes a protein with 184 amino acid residues and a molecular weight of ~20.9 kDa (20,47,50)